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Comprehensive assessment of oxidative stress degrees and anti-oxidant potential in dialysis patients Miyagawa, Akemi Tateishi, Kinya 491.4 d-ROMs BAP Dialysis treatment Oxidative stress Anti-oxidant potential 香川県立保健医療大学 博士（臨床検査学） application/pdf Thesis or Dissertation When the kidney is compromised, oxidative stress is aggravated by an increased rate of reactive oxygen species generation and a decreased rate of substance elimination. In addition, dialysis treatment itself is reported to be associated with oxidative stress in patients with terminal renal insufficiency. This study was conducted to determine the optimum dialysis treatment. Diacronreactive oxygen metabolite and biological anti-oxidant potential tests were performed to assess oxidative stress levels. Increased oxidative stress and decreased anti-oxidant potential were found immediately after dialysis. A comparison of dialysis membranes revealed that ABH®-PA membranes exhibited a significantly lower rate of decrease in anti-oxidant potential in terms of oxidative stress compared with Maxiflux® membranes. Analysis of biochemical parameters identified significant strong positive correlations between diacron-reactive oxygen metabolites test results and serum total protein, serum albumin, total cholesterol, high-density lipoprotein-cholesterol, and low-density lipoprotein-cholesterol for the percentage decrease and between biological anti-oxidant potential test results and inorganic phosphorus for pre-dialysis measurements. ABH®-PA should be used as the dialysis membrane to minimize the increase in the degree of oxidative stress caused by dialysis treatment. We recommend measuring serum total protein, serum albumin, total cholesterol, and inorganic phosphorus before and after dialysis sessions to better understand oxidative stress degrees and anti-oxidant potential. doctoral thesis The Society of Analytical Bio-Science The Society of Analytical Bio-Science 2020-12-31 2020-09-16 VoR application/pdf application/pdf application/pdf International Journal of Analytical Bio-Science 4 8 83 92 甲第2号 21877912 https://kagawa-puhs.repo.nii.ac.jp/record/337/files/DS2_論文本文.pdf https://kagawa-puhs.repo.nii.ac.jp/record/337/files/DS2_abstract.pdf https://kagawa-puhs.repo.nii.ac.jp/record/337/files/DS2_Result .pdf https://doi.org/10.50850/00000331 https://kagawa-puhs.repo.nii.ac.jp/records/337 eng https://kagawa-puhs.repo.nii.ac.jp/?action=pages_view_main&active_action=repository_view_main_item_detail&item_id=337&item_no=1&page_id=13&block_id=21 40022452841 open access open access