@phdthesis{oai:kagawa-puhs.repo.nii.ac.jp:00000339,
 author = {Morinishi, Tatsuya and Tokuhara, Yasunori and Ohsaki, Hiroyuki and Ibuki, Emi and Kadota, Kyuichi and Hirakawa, Eiichiro},
 month = {Jul},
 note = {application/pdf, Thesis or Dissertation, Peroxisome proliferator-activated receptor alpha (PPAR-????) belongs to the PPAR family and plays a critical role in inhibiting cell proliferation and tumorigenesis in various tumors.However, the role of PPAR-???? in colorectal tumorigenesis is unclear. In the present study, we found that fenofibrate, a PPAR-???? agonist, significantly inhibited cell proliferation and induced apoptosis in colorectal
carcinoma cells. In addition, PPAR-???? was expressed in the nucleus of colorectal carcinoma cells, and the expression of nuclear PPAR-???? increased in colorectal carcinoma tissue compared with that of normal epitheliumtissue (P<0.01).Thecorrelation between the expression of nuclear PPAR-???? and clinicopathological factors was evaluated in human colorectal carcinoma tissues, and the
nuclear expression of PPAR-???? was significantly higher in well-to-moderately differentiated adenocarcinoma than in mucinous adenocarcinoma (P<0.05). These findings indicate that activation of PPAR-???? may be involved in anticancer effects in colorectal carcinomas, and nuclear expression of PPAR-???? may be a therapeutic target for colorectal adenocarcinoma treatment.},
 school = {香川県立保健医療大学},
 title = {Activation and Expression of Peroxisome Proliferator-Activated Receptor Alpha Are Associated with Tumorigenesis in Colorectal Carcinoma},
 year = {2019}
}