{"created":"2023-06-19T06:42:11.159832+00:00","id":339,"links":{},"metadata":{"_buckets":{"deposit":"bcd1789f-da2a-4722-9823-ecae18e59c45"},"_deposit":{"created_by":5,"id":"339","owners":[5],"pid":{"revision_id":0,"type":"depid","value":"339"},"status":"published"},"_oai":{"id":"oai:kagawa-puhs.repo.nii.ac.jp:00000339","sets":["38:101"]},"author_link":["1470","1471","1468","1456","1469","1467"],"item_10006_biblio_info_27":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-07-03","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"9","bibliographicPageStart":"1","bibliographic_titles":[{},{"bibliographic_title":"PPAR Research","bibliographic_titleLang":"en"}]}]},"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2020-03-10"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"香川県立保健医療大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"26201","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（臨床検査学）"}]},"item_10006_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10006_description_30":{"attribute_name":"NIItype","attribute_value_mlt":[{"subitem_description":"Thesis or Dissertation","subitem_description_type":"Other"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Peroxisome proliferator-activated receptor alpha (PPAR-????) belongs to the PPAR family and plays a critical role in inhibiting cell proliferation and tumorigenesis in various tumors.However, the role of PPAR-???? in colorectal tumorigenesis is unclear. In the present study, we found that fenofibrate, a PPAR-???? agonist, significantly inhibited cell proliferation and induced apoptosis in colorectal\ncarcinoma cells. In addition, PPAR-???? was expressed in the nucleus of colorectal carcinoma cells, and the expression of nuclear PPAR-???? increased in colorectal carcinoma tissue compared with that of normal epitheliumtissue (P<0.01).Thecorrelation between the expression of nuclear PPAR-???? and clinicopathological factors was evaluated in human colorectal carcinoma tissues, and the\nnuclear expression of PPAR-???? was significantly higher in well-to-moderately differentiated adenocarcinoma than in mucinous adenocarcinoma (P<0.05). These findings indicate that activation of PPAR-???? may be involved in anticancer effects in colorectal carcinomas, and nuclear expression of PPAR-???? may be a therapeutic target for colorectal adenocarcinoma treatment.","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第1号"}]},"item_10006_link_29":{"attribute_name":"出版社版","attribute_value_mlt":[{"subitem_link_text":"PPAR Research_2019_7486727","subitem_link_url":"https://www.hindawi.com/journals/ppar/2019/7486727/"}]},"item_10006_publisher_28":{"attribute_name":"出版社","attribute_value_mlt":[{"subitem_publisher":"Hindawi"}]},"item_10006_publisher_5":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"Hindawi"}]},"item_10006_relation_14":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kagawa-puhs.repo.nii.ac.jp/?action=pages_view_main&active_action=repository_view_main_item_detail&item_id=339&item_no=1&page_id=13&block_id=21"}]}]},"item_10006_relation_25":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"31354797","subitem_relation_type_select":"PMID"}}]},"item_10006_relation_26":{"attribute_name":"論文ID","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"120006709588","subitem_relation_type_select":"NAID"}}]},"item_10006_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"open access"},{"subitem_rights":"Copyright © 2019 Tatsuya Morinishi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited."}]},"item_10006_source_id_23":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"16874757","subitem_source_identifier_type":"ISSN"}]},"item_10006_source_id_24":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12156341","subitem_source_identifier_type":"NCID"}]},"item_10006_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"493.465","subitem_subject_scheme":"NDC"}]},"item_10006_text_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_text_value":"2019"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Morinishi, Tatsuya","creatorNameLang":"en"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Tokuhara, Yasunori","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ohsaki, Hiroyuki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ibuki, Emi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kadota, Kyuichi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hirakawa, Eiichiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-10-22"}],"displaytype":"detail","filename":"DS1_論文本文.pdf","filesize":[{"value":"3.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"本文","url":"https://kagawa-puhs.repo.nii.ac.jp/record/339/files/DS1_論文本文.pdf"},"version_id":"c29d84cb-15b8-4d12-bdf0-8edf9acbc4a8"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-10-22"}],"displaytype":"detail","filename":"DS1_abstract.pdf","filesize":[{"value":"345.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Abstract","url":"https://kagawa-puhs.repo.nii.ac.jp/record/339/files/DS1_abstract.pdf"},"version_id":"7b5e7eac-452e-4036-b829-6f26c2854178"},{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-10-22"}],"displaytype":"detail","filename":"DS1_result.pdf","filesize":[{"value":"86.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Result","url":"https://kagawa-puhs.repo.nii.ac.jp/record/339/files/DS1_result.pdf"},"version_id":"60c97063-5b1f-4c4f-92fb-7a8b05ca3c6f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"PPAR-α","subitem_subject_scheme":"Other"},{"subitem_subject":"大腸癌","subitem_subject_scheme":"Other"},{"subitem_subject":"アポトーシス","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Activation and Expression of Peroxisome Proliferator-Activated Receptor Alpha Are Associated with Tumorigenesis in Colorectal Carcinoma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Activation and Expression of Peroxisome Proliferator-Activated Receptor Alpha Are Associated with Tumorigenesis in Colorectal Carcinoma","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"5","path":["101"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-10-22"},"publish_date":"2020-10-22","publish_status":"0","recid":"339","relation_version_is_last":true,"title":["Activation and Expression of Peroxisome Proliferator-Activated Receptor Alpha Are Associated with Tumorigenesis in Colorectal Carcinoma"],"weko_creator_id":"5","weko_shared_id":-1},"updated":"2023-06-19T06:45:15.454844+00:00"}