{"created":"2023-06-19T06:42:11.773670+00:00","id":358,"links":{},"metadata":{"_buckets":{"deposit":"17acb002-bebd-4aba-89d7-d65d3f1030b7"},"_deposit":{"created_by":5,"id":"358","owners":[5],"pid":{"revision_id":0,"type":"depid","value":"358"},"status":"published"},"_oai":{"id":"oai:kagawa-puhs.repo.nii.ac.jp:00000358","sets":["38","38:101"]},"author_link":["1528","1527","1526","1530","1529","1525","1523","1524"],"item_10006_biblio_info_27":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-12-16","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageStart":"36","bibliographicVolumeNumber":"16","bibliographic_titles":[{},{"bibliographic_title":"Molecular and Clinical Oncology","bibliographic_titleLang":"en"}]}]},"item_10006_date_granted_11":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2022-03-08"}]},"item_10006_degree_grantor_9":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"香川県立保健医療大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"26201","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_10006_degree_name_8":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（臨床検査学）"}]},"item_10006_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10006_description_7":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Peroxisome proliferator‑activated receptor‑γ(PPAR‑γ) is a well‑known nuclear receptor that is activated in the nucleus to regulate several transcription factors. Its expression patterns have been examined in various types of cancer. The present study investigated the expression patterns of PPAR‑γ in non‑muscle‑invasive urothelial carcinoma. The expression rates of PPAR‑γ, p53 and Ki‑67 were compared to determine whether PPAR‑γ may be considered as an immunobiomarker for bladder cancer. The intensity and extent of PPAR‑γ expression were evaluated in 79 cases of non‑muscle‑invasive urothelial carcinoma (30 cases of papillary carcinoma low‑grade, 30 cases of high‑grade and 19 cases of carcinoma in situ) and 30 non‑malignant cases. The nuclear overexpression of PPAR‑γ was frequently observed in non‑muscle‑invasive urothelial carcinoma (63/79 cases) but was rarely detected in non‑malignant cases (2/30 cases). The histological proliferation types of non‑muscle‑invasive urothelial carcinoma revealed that PPAR‑γ was more frequently overexpressed in papillary carcinoma (54/60 cases) than in carcinoma in situ (9/19 cases). Immunohistochemical staining demonstrated that PPAR‑γ was more useful as an immunobiomarker than p53 or Ki‑67 (diagnostic odds ratios; 55.13, 16.82 and 11.13, respectively). In summary, this study demonstrated that the expression patterns of PPAR‑γ were associated with histological proliferation type and that PPAR‑γ was expressed in the nuclei of papillary carcinoma cells. These findings suggested that immunohistochemical staining for PPAR‑γ may be used to comprehensively detect non‑muscle‑invasive urothelial carcinoma.","subitem_description_type":"Abstract"}]},"item_10006_dissertation_number_12":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第5号"}]},"item_10006_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.50850/00000346","subitem_identifier_reg_type":"JaLC"}]},"item_10006_link_29":{"attribute_name":"出版社版","attribute_value_mlt":[{"subitem_link_text":"Molecular and Clinical Oncology","subitem_link_url":"https://www.spandidos-publications.com/10.3892/mco.2021.2469"}]},"item_10006_publisher_28":{"attribute_name":"出版社","attribute_value_mlt":[{"subitem_publisher":"Spandidos Publications"}]},"item_10006_publisher_5":{"attribute_name":"公開者","attribute_value_mlt":[{"subitem_publisher":"Spandidos Publications"}]},"item_10006_relation_15":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"Molecular and Clinical Oncology:Information for authors(10.Author self-archiving)"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.spandidos-publications.com/pages/mco/info_for_authors","subitem_relation_type_select":"URI"}}]},"item_10006_relation_25":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"34984103","subitem_relation_type_select":"PMID"}}]},"item_10006_rights_13":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"open access"},{"subitem_rights":"Copyright: © Tanaka et al.This is an open access article distributed under the Creative Commons Attribution License."}]},"item_10006_source_id_23":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"20499450","subitem_source_identifier_type":"ISSN"}]},"item_10006_text_10":{"attribute_name":"学位授与年度","attribute_value_mlt":[{"subitem_text_value":"2021"}]},"item_10006_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tanaka, Shinichi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tokuhara, Yasunori","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hosokawa, Sho","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ohsaki, Hiroyuki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Morinishi, Tatsuya","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamamoto, Tamami","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Teramoto, Norihiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hirakawa, Eiichiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-10-07"}],"displaytype":"detail","filename":"DS4_論文本文.pdf","filesize":[{"value":"2.1 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primary Ta/T1 non‑muscle‑invasive urothelial carcinoma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Overexpression of the PPAR‑γ protein in primary Ta/T1 non‑muscle‑invasive urothelial carcinoma","subitem_title_language":"en"}]},"item_type_id":"10006","owner":"5","path":["38","101"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-10-12"},"publish_date":"2022-10-12","publish_status":"0","recid":"358","relation_version_is_last":true,"title":["Overexpression of the PPAR‑γ protein in primary Ta/T1 non‑muscle‑invasive urothelial carcinoma"],"weko_creator_id":"5","weko_shared_id":-1},"updated":"2023-06-19T06:44:52.119971+00:00"}