| Item type |
学位論文 / Thesis or Dissertation(1) |
| 公開日 |
2022-10-12 |
| タイトル |
|
|
タイトル |
Overexpression of the PPAR‑γ protein in primary Ta/T1 non‑muscle‑invasive urothelial carcinoma |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Peroxisome proliferator‑activated receptor‑γ |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Non‑muscle‑invasive urothelial carcinoma |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Immunohistochemical staining |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_db06 |
|
資源タイプ |
doctoral thesis |
| ID登録 |
|
|
ID登録 |
10.50850/00000346 |
|
ID登録タイプ |
JaLC |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
Tanaka, Shinichi
Tokuhara, Yasunori
Hosokawa, Sho
Ohsaki, Hiroyuki
Morinishi, Tatsuya
Yamamoto, Tamami
Teramoto, Norihiro
Hirakawa, Eiichiro
|
| 公開者 |
|
|
出版者 |
Spandidos Publications |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Peroxisome proliferator‑activated receptor‑γ(PPAR‑γ) is a well‑known nuclear receptor that is activated in the nucleus to regulate several transcription factors. Its expression patterns have been examined in various types of cancer. The present study investigated the expression patterns of PPAR‑γ in non‑muscle‑invasive urothelial carcinoma. The expression rates of PPAR‑γ, p53 and Ki‑67 were compared to determine whether PPAR‑γ may be considered as an immunobiomarker for bladder cancer. The intensity and extent of PPAR‑γ expression were evaluated in 79 cases of non‑muscle‑invasive urothelial carcinoma (30 cases of papillary carcinoma low‑grade, 30 cases of high‑grade and 19 cases of carcinoma in situ) and 30 non‑malignant cases. The nuclear overexpression of PPAR‑γ was frequently observed in non‑muscle‑invasive urothelial carcinoma (63/79 cases) but was rarely detected in non‑malignant cases (2/30 cases). The histological proliferation types of non‑muscle‑invasive urothelial carcinoma revealed that PPAR‑γ was more frequently overexpressed in papillary carcinoma (54/60 cases) than in carcinoma in situ (9/19 cases). Immunohistochemical staining demonstrated that PPAR‑γ was more useful as an immunobiomarker than p53 or Ki‑67 (diagnostic odds ratios; 55.13, 16.82 and 11.13, respectively). In summary, this study demonstrated that the expression patterns of PPAR‑γ were associated with histological proliferation type and that PPAR‑γ was expressed in the nuclei of papillary carcinoma cells. These findings suggested that immunohistochemical staining for PPAR‑γ may be used to comprehensively detect non‑muscle‑invasive urothelial carcinoma. |
| 学位名 |
|
|
学位名 |
博士（臨床検査学） |
| 学位授与機関 |
|
|
|
学位授与機関識別子Scheme |
kakenhi |
|
|
学位授与機関識別子 |
26201 |
|
|
学位授与機関名 |
香川県立保健医療大学 |
| 学位授与年度 |
|
|
|
2021 |
| 学位授与年月日 |
|
|
学位授与年月日 |
2022-03-08 |
| 学位授与番号 |
|
|
学位授与番号 |
甲第5号 |
| 権利 |
|
|
権利情報 |
open access |
| 権利 |
|
|
権利情報 |
Copyright: © Tanaka et al.This is an open access article distributed under the Creative Commons Attribution License. |
| 関連サイト |
|
|
|
識別子タイプ |
URI |
|
|
関連識別子 |
https://www.spandidos-publications.com/pages/mco/info_for_authors |
|
|
関連名称 |
Molecular and Clinical Oncology:Information for authors(10.Author self-archiving) |
| フォーマット |
|
|
内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 書誌情報 |
en : Molecular and Clinical Oncology
巻 16,
号 3,
p. 36,
発行日 2021-12-16
|
| 出版社 |
|
|
出版者 |
Spandidos Publications |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
20499450 |
| PubMed番号 |
|
|
|
識別子タイプ |
PMID |
|
|
関連識別子 |
34984103 |
| 出版社版 |
|
|
|
Molecular and Clinical Oncology |
|
|
https://www.spandidos-publications.com/10.3892/mco.2021.2469 |
本文 (2.1 MB)
