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Activation and Expression of Peroxisome Proliferator-Activated Receptor Alpha Are Associated with Tumorigenesis in Colorectal Carcinoma
https://kagawa-puhs.repo.nii.ac.jp/records/339
https://kagawa-puhs.repo.nii.ac.jp/records/339130526b1-d5e5-4561-9b59-a82060099b08
| 名前 / ファイル | ライセンス | アクション |
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本文 (3.1 MB)
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Abstract (345.1 kB)
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Result (86.6 kB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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| 公開日 | 2020-10-22 | |||||
| タイトル | ||||||
| タイトル | Activation and Expression of Peroxisome Proliferator-Activated Receptor Alpha Are Associated with Tumorigenesis in Colorectal Carcinoma | |||||
| 言語 | en | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | PPAR-α | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | 大腸癌 | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | アポトーシス | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
| 資源タイプ | doctoral thesis | |||||
| アクセス権 | ||||||
| アクセス権 | open access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
| 著者 |
Morinishi, Tatsuya
× Morinishi, Tatsuya× Tokuhara, Yasunori× Ohsaki, Hiroyuki× Ibuki, Emi× Kadota, Kyuichi× Hirakawa, Eiichiro |
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| 公開者 | ||||||
| 出版者 | Hindawi | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Peroxisome proliferator-activated receptor alpha (PPAR-????) belongs to the PPAR family and plays a critical role in inhibiting cell proliferation and tumorigenesis in various tumors.However, the role of PPAR-???? in colorectal tumorigenesis is unclear. In the present study, we found that fenofibrate, a PPAR-???? agonist, significantly inhibited cell proliferation and induced apoptosis in colorectal carcinoma cells. In addition, PPAR-???? was expressed in the nucleus of colorectal carcinoma cells, and the expression of nuclear PPAR-???? increased in colorectal carcinoma tissue compared with that of normal epitheliumtissue (P<0.01).Thecorrelation between the expression of nuclear PPAR-???? and clinicopathological factors was evaluated in human colorectal carcinoma tissues, and the nuclear expression of PPAR-???? was significantly higher in well-to-moderately differentiated adenocarcinoma than in mucinous adenocarcinoma (P<0.05). These findings indicate that activation of PPAR-???? may be involved in anticancer effects in colorectal carcinomas, and nuclear expression of PPAR-???? may be a therapeutic target for colorectal adenocarcinoma treatment. |
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| 学位名 | ||||||
| 学位名 | 博士（臨床検査学） | |||||
| 学位授与機関 | ||||||
| 学位授与機関識別子Scheme | kakenhi | |||||
| 学位授与機関識別子 | 26201 | |||||
| 学位授与機関名 | 香川県立保健医療大学 | |||||
| 学位授与年度 | ||||||
| 値 | 2019 | |||||
| 学位授与年月日 | ||||||
| 学位授与年月日 | 2020-03-10 | |||||
| 学位授与番号 | ||||||
| 学位授与番号 | 甲第1号 | |||||
| 権利 | ||||||
| 権利情報 | open access | |||||
| 権利 | ||||||
| 権利情報 | Copyright © 2019 Tatsuya Morinishi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | |||||
| 情報源 | ||||||
| 関連名称 | https://kagawa-puhs.repo.nii.ac.jp/?action=pages_view_main&active_action=repository_view_main_item_detail&item_id=339&item_no=1&page_id=13&block_id=21 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 493.465 | |||||
| 書誌情報 |
en : PPAR Research p. 1-9, 発行日 2019-07-03 |
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| 出版社 | ||||||
| 出版者 | Hindawi | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 16874757 | |||||
| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA12156341 | |||||
| 論文ID | ||||||
| 識別子タイプ | NAID | |||||
| 関連識別子 | 120006709588 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 31354797 | |||||
| 出版社版 | ||||||
| 表示名 | PPAR Research_2019_7486727 | |||||
| URL | https://www.hindawi.com/journals/ppar/2019/7486727/ | |||||
| NIItype | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Thesis or Dissertation | |||||
